news

Sensitization test detection of cell factories

Mon Mar 14 11:57:53 CST 2022

The sensitization test is a test to determine whether the test substance is an allergen and the sensitization intensity. As a cell consumable commonly used in large-scale cell or tissue culture, cell factories also need to be subjected to sensitization tests to determine whether they contain allergens and sensitization strength.

The phenomenon in which the specific sensitivity of the body to an antigenic or haptenic chemical is increased. Chemicals that have a sensitizing effect are called chemoallergens or chemosensitizers. Chemical sensitizers act on the body through various ways, and can make immune active cells in the body produce specific immune responses to them. symptoms and signs. If the cell factory contains allergens, it will affect the growth and proliferation of cells.

The sensitization test animals are mostly guinea pigs, and the test substances are mostly pure chemical products. The dose to be used is determined experimentally, starting with the maximum dose that does not produce symptoms of systemic toxicity or local irritation. The number of exposures can be one or more. The challenge test is carried out 2 to 4 weeks after the last sensitization exposure, and the presence or absence of sensitization and the intensity of sensitization are determined according to local or systemic reactions.

Through the sensitization test of the cell factory, it can be judged whether it contains chemical allergens, so as to identify whether the product quality is qualified or not, and to ensure the smooth progress of the later cell culture test.

The FAI climbed 5.9 percent year-on-year in the first 11 months of 2018, quickening from the 5.7-percent growth in Jan-Oct, the National Bureau of Statistics (NBS) said Friday in an online statement.

The key indicator of investment, dubbed a major growth driver, hit the bottom in August and has since started to rebound steadily.

In the face of emerging economic challenges home and abroad, China has stepped up efforts to stabilize investment, in particular rolling out measures to motivate private investors and channel funds into infrastructure.

Friday's data showed private investment, accounting for more than 60 percent of the total FAI, expanded by a brisk 8.7 percent.

NBS spokesperson Mao Shengyong said funds into weak economic links registered rapid increases as investment in environmental protection and agriculture jumped 42 percent and 12.5 percent respectively, much faster than the average.

In breakdown, investment in high-tech and equipment manufacturing remained vigorous with 16.1-percent and 11.6-percent increases respectively in the first 11 months. Infrastructure investment gained 3.7 percent, staying flat. Investment in property development rose 9.7 percent, also unchanged.