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How to achieve sterility requirements in sterile media bottles

Thu May 26 11:12:25 CST 2022

Cell culture needs to be carried out in a sterile environment, and serum, which is a nutrient for cell growth, must also be aseptically processed before it can be used. In order to ensure the sterility of the serum, qualified sterile media bottles must also meet the sterility requirements.

The sterile media bottle is generally made of transparent PET material, which has good low temperature resistance and impact resistance, is non-toxic and tasteless, and has high transparency. It is an excellent packaging material. In the sterilization method, this kind of bottle is generally sterilized by electron beam irradiation. Electron beam irradiation is a technique commonly used for the sterilization of pharmaceutical packaging products and medical devices. It works by directing a continuous flow of electrons through the item being sterilized. The transfer of electron beam energy breaks the DNA chain in the organism, allowing the It loses its activity and the irradiated article becomes sterile.

Electron beam sterilization is convenient, gentle, effective, and can be performed continuously on the final packaged product. It operates at a much lower temperature than steam sterilization and is suitable for products with hard-to-reach areas (eg, cartridges with lids). Compared to gamma radiation, it has a much lower risk of degradation (due to shorter exposure times); compared to ethylene oxide exposure, it eliminates the risk of ethylene oxide absorption and subsequent penetration into the drug product.

The sterile media bottle after electron beam sterilization can reach a sterile state and meet the storage requirements of serum, which is of great significance for the orderly growth of cells.

The FAI climbed 5.9 percent year-on-year in the first 11 months of 2018, quickening from the 5.7-percent growth in Jan-Oct, the National Bureau of Statistics (NBS) said Friday in an online statement.

The key indicator of investment, dubbed a major growth driver, hit the bottom in August and has since started to rebound steadily.

In the face of emerging economic challenges home and abroad, China has stepped up efforts to stabilize investment, in particular rolling out measures to motivate private investors and channel funds into infrastructure.

Friday's data showed private investment, accounting for more than 60 percent of the total FAI, expanded by a brisk 8.7 percent.

NBS spokesperson Mao Shengyong said funds into weak economic links registered rapid increases as investment in environmental protection and agriculture jumped 42 percent and 12.5 percent respectively, much faster than the average.

In breakdown, investment in high-tech and equipment manufacturing remained vigorous with 16.1-percent and 11.6-percent increases respectively in the first 11 months. Infrastructure investment gained 3.7 percent, staying flat. Investment in property development rose 9.7 percent, also unchanged.