Application of cell factory in the preparation of oral inactivated polio vaccine

Wed Jun 22 11:23:26 CST 2022

Cell culture needs to be carried out in a specific container. The cell factory is a multi-layered cell culture consumable, which is mainly used for the large-scale culture of adherent cells. This consumable is used in the preparation of oral inactivated polio vaccine.

Polio is an acute infectious disease caused by the poliovirus. The clinical manifestations are mainly fever, upper respiratory tract symptoms, and limb pain. The virus mainly invades the gray and white parts of the anterior horn of the human spinal cord, causing permanent damage to the gray matter, resulting in flaccid paralysis of the limbs. Some patients may develop delayed nerve palsy and leave paralysis sequelae, which are generally more common in children under the age of 5, so it is commonly known as "polio". The disease is preventable and refractory, and once it causes limb paralysis, it can easily become life-long disability or even life-threatening. Vaccination is an economical and effective way to prevent and control the spread of polio.

cell factory

The production of inactivated vaccines requires processes such as cell culture, virus inoculation, virus inactivation, purification and concentration, antigen preservation, emulsification and vaccine preparation, and packaging. Cell factories are mainly used in the large-scale cell culture stage. In terms of specifications, it is mainly 10 layers or 40 layers. When selecting large-scale consumables, it is generally necessary to use automatic machines to operate, which is convenient for container rotation and liquid transfer.

The above is the application of cell factory in the preparation of oral inactivated polio vaccine. It is not only used in the production of various vaccines, but also in the fields of biopharmaceuticals, cell and gene therapy, etc.It has become the mainstream consumable for large-scale cell culture.

The FAI climbed 5.9 percent year-on-year in the first 11 months of 2018, quickening from the 5.7-percent growth in Jan-Oct, the National Bureau of Statistics (NBS) said Friday in an online statement.

The key indicator of investment, dubbed a major growth driver, hit the bottom in August and has since started to rebound steadily.

In the face of emerging economic challenges home and abroad, China has stepped up efforts to stabilize investment, in particular rolling out measures to motivate private investors and channel funds into infrastructure.

Friday's data showed private investment, accounting for more than 60 percent of the total FAI, expanded by a brisk 8.7 percent.

NBS spokesperson Mao Shengyong said funds into weak economic links registered rapid increases as investment in environmental protection and agriculture jumped 42 percent and 12.5 percent respectively, much faster than the average.

In breakdown, investment in high-tech and equipment manufacturing remained vigorous with 16.1-percent and 11.6-percent increases respectively in the first 11 months. Infrastructure investment gained 3.7 percent, staying flat. Investment in property development rose 9.7 percent, also unchanged.