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Application of cell factories in large-scale cell culture

Tue Mar 29 15:27:51 CST 2022

Large-scale cell culture technology refers to the technology of artificially controlling environmental conditions and cultivating useful microorganisms, animal and plant cells on a large scale with high density. It is the basis for a large number of new cells obtained by gene recombination, cell fusion and other technologies in industrial production such as food and medicine. Cell factories are commonly used consumables in large-scale cell culture.

The common layers of cell factories include 1 layer, 2 layers, 5 layers, 10 layers, 40 layers, etc., which are mainly suitable for the culture of adherent cells. To expand its training scale, it can be achieved by increasing the number of layers. This training method can maximize the utilization of large space, save plant space, and save manpower and material resources.

In industry, cell factories are widely used in mass production of vaccines, monoclonal antibodies or the pharmaceutical industry. Common animal cells that have been cultured on a large scale include chicken embryo fibroblasts, primary hamster kidney cells and other primary cells, as well as human diploid cells, CHO cells, and Vero cells. These cells are widely used in vaccine production, monoclonal antibody preparation, erythropoietin and other product fields.

In addition, large-scale cell culture through cell factories can reduce the number of cell culture devices and reduce the risk of cell contamination. It is an efficient cell culture consumable and is favored by many scientific research institutions and pharmaceutical companies.

The FAI climbed 5.9 percent year-on-year in the first 11 months of 2018, quickening from the 5.7-percent growth in Jan-Oct, the National Bureau of Statistics (NBS) said Friday in an online statement.

The key indicator of investment, dubbed a major growth driver, hit the bottom in August and has since started to rebound steadily.

In the face of emerging economic challenges home and abroad, China has stepped up efforts to stabilize investment, in particular rolling out measures to motivate private investors and channel funds into infrastructure.

Friday's data showed private investment, accounting for more than 60 percent of the total FAI, expanded by a brisk 8.7 percent.

NBS spokesperson Mao Shengyong said funds into weak economic links registered rapid increases as investment in environmental protection and agriculture jumped 42 percent and 12.5 percent respectively, much faster than the average.

In breakdown, investment in high-tech and equipment manufacturing remained vigorous with 16.1-percent and 11.6-percent increases respectively in the first 11 months. Infrastructure investment gained 3.7 percent, staying flat. Investment in property development rose 9.7 percent, also unchanged.